Vivax Doubily Bnwerse Than Falciparum

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Vivax Doubily Bnwerse Than Falciparum

 

The international research team sequenced and annotated the genomes of four P. vivax strains collected from various geographic locations thus tri­pling the number of genome sequences available for this understudied parasite.

Researchers sequencing the genom­es of four strains of the malaria-causing parasite Plasmodium vivax, including one strain from India — have found it to be almost twice as genetically diverse as its lethal cousin Plasmodium falci­parum. The finding suggests a capacity for ‘greater functional variation in the global population of P. vivax.
Half the world’s population is estimated to be at risk for malaria caused by P. vivax while P. falcipa­rum is responsible for majority of the contemporary malaria-related mor­tality. However, studies say P. vivax was virulent before the advent of modern medicine. More recently, research has shown that P. vivax is capable of causing the severe malaria syndromes that have long been attrib­uted only to P. falciparum.
The international research team sequenced and annotated the genomes of four P. vivax strains collected from various geographic locations thus tri­pling the number of genome sequences available for this understudied parasite. The study provides the first genome­wide perspective of global variability in this species. The four newly sequenced P. vivax strains (North Korean, India VII, Mauritania I and Brazil I) were from genomic DNA derived from leukocyte-depleted monkey blood. The P. falciparum isolates (from Honduras, India, Indochina and Senegal) were se­quenced using template derived fromin vitro cultures.
The team observed, approximately, twice as much Single Nucleotide Poly­morphism (SNP) diversity among these isolates as among a comparable collec­tion of isolates of P. falciparum. They say this indicates a distinct history of global colonization and/or a stable demographic history for P. vivax relative to P. falciparum.
The SNP diversity, as well as additional microsatellite and gene family variability, suggests a capacity for greater functional variation in the global population of P. vivax, research reported. Adding that there’s need for a deeper survey of variation in P. vivax. This will aid diagnosis and treatment of malaria caused by this neglected but major pathogen

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